Integrative Pharmaceuticals and Innovation of Pharmaceutical Technology Research Unit (INPHINITY RU)

Introduction

Integrative Pharmaceuticals and Innovation of Pharmaceutical Technology Research Unit (INPHINITY RU) was established in 2022 from the collaborations of the researchers who are interested in the integrative pharmaceutical sciences and products development by using innovation of pharmaceutical technology from the Faculty of Pharmacy and Faculty of Medicine, Mahasarakham University. INPHINITY RU aims to create knowledge, develop products, provide academic services and transfer knowledge from the integrated pharmaceutical chemistry, pharmacognosy, pharmaceutical botany, pharmaceutical biotechnology and pharmaceutical technology.

Research scopes

• Integrated from pharmaceutical chemistry, pharmacognosy, pharmaceutical botany, pharmaceutical biotechnology, and pharmaceutical technology
• Product developments by using innovation of pharmaceutical technology

Highlights

• Impact of membranes on in vitro release assessment
• Determination of a chemical marker in Dipterocarpus alatus oleoresin samples and bioactivity screening via antioxidants, nitric oxide inhibition on murine RAW 264.7 cells, and collagen production on normal human dermal fibroblasts
• Molecular insights into complex formation between scandenin and various types of β-cyclodextrin
• Local wisdom and medicinal plant utilization of certified folk healers for therapeutic purposes
• Inhibitory effect of leaf, bark and twig of Dipterocarpus alatus on the inflammation mediators, nitric oxide, PGE2, IL-1β and TNF-α in macrophage RAW 264.7
• Impact of pineapple on mitochondrial permeability transition and drug metabolizing genes in Caco-2 cells
• Purple waxy corn modifies the expression of CYP3A4, N-acetyltransferase 2, and UGT1A6 in HepG2 and Caco-2 cells
• Plumbagin and Plumbago indica differentially modulated cytochrome p450 and transporter profiles in BeWo and HepG2 cells
• Anti-inflammatory activity and quantitative analysis of major compounds of the mixtures of Derris scandens (DZSS) Formula
• Influence of in vitro release methods on assessment of tobramycin ophthalmic ointments
• Flavonoids kaempferide and 4,2′-dihydroxy-4′,5′,6′-trimethoxychalcone inhibit mitotic clonal expansion and induce apoptosis during the early phase of adipogenesis in 3T3-L1 cells
• Melatonin and its derivative contents in tropical fruits and fruit tablets
• Effect of storage and packaging conditions on physical properties and carotenoid content of mango tablets
• Development of Tagetes erecta flower serum
• Development of anthocyanin complex niosome gel
• Development of Kaempferia parviflora nanosuspension
• Development of Triphala serum
• Development of chewing gum containing mulberry leaf extract

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